The overarching goal of the Jost lab is to define the molecular mechanisms of host-microbiome communication using a combination of systematic CRISPR technologies, physiological cell models such as organoids, and an interdisciplinary set of targeted...
Diabetes and Obesity Genetics. The Soukas Laboratory in the Center for Human Genetic Research and the Diabetes Unit at the MGH seeks to understand the pathogenesis of obesity and diabetes, and to identify new therapeutic targets for these common...
We are developing a training environment where we apply emerging techniques...
Tracy Young-Pearse's research group focuses on two main areas.
The laboratory focuses on the developmental biology of hematopoiesis and cancer. We have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. We also have undertaken...
Our laboratory studies how chromosome behavior and positioning influence genome function and evolution, with implications for gene regulation, genome stability, and diseases such as cancer and neurodevelopmental disorders. Using mammals, Drosophila, and...
A critical step in eukaryotic gene regulation is the control of transcription across the chromatin template. While transcription has been extensively studied for many years, there are still many mysteries regarding its function and regulation...
My laboratory’s research focuses on the skeletal system. We employ a “bedside to bench to bedside” approach in order to delineate biologic pathways that are essential for skeletal health. Our research questions originate from patients with heritable...
Within cells macromolecules form complex intertwined networks of functionally interacting components. The molecular mechanisms underlying biological processes correspond to particular steady states adopted by such cellular networks. Systems-level...
